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SNCA antibody (Synuclein, alpha) (AA 61-95)

Details for Product anti-SNCA Antibody No. ABIN121176, Supplier: Log in to see
Antigen
  • alphaSYN
  • LOC619283
  • MGC64356
  • NACP
  • PARK1
  • PARK4
  • PD1
  • snca
Epitope
AA 61-95
70
47
42
39
36
35
28
19
13
12
12
10
7
6
6
5
5
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
610
262
257
16
14
11
11
8
4
2
2
2
1
1
1
Host
Mouse
404
190
33
10
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This SNCA antibody is un-conjugated
27
26
21
11
11
6
6
6
6
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
468
248
130
123
78
67
51
21
16
16
9
7
2
2
1
1
1
1
1
Supplier
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Immunogen Recombinant human a -synuclein (1-140) purified from E. coli
Clone 5C2
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity Chromatography on Protein G
Alternative Name alpha-Synuclein / SNCA (SNCA Antibody Abstract)
Background Alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Specially, the non-A beta component of amyloid plaques (NAC, amino acids 61-95) is a highly amyloidogenic peptide consisting of 35 amino acids which was first identified associated with senile plaques in the Alzheimer's disease brain.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
UniProt P37840
Research Area Neurology
Application Notes ELISA. Western blot (1:500 - 1:2,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Background publications Paik, Lee, Kim, Chang, Kim: "Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid." in: Archives of biochemistry and biophysics, Vol. 344, Issue 2, pp. 325-34, 1997 (PubMed).

Jakes, Spillantini, Goedert: "Identification of two distinct synucleins from human brain." in: FEBS letters, Vol. 345, Issue 1, pp. 27-32, 1994 (PubMed).