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TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1)

Details for Product anti-NTRK1 Antibody No. ABIN127050, Supplier: Log in to see
Antigen
  • C80751
  • CAPM1
  • CFTD
  • CTRKA
  • hscp30
  • MTC
  • NEM1
  • OK/SW-cl.5
  • p140-TrkA
  • Tkr
  • TM-5
  • TM3
  • TM5
  • TM30
  • TM30nm
  • TPMsk3
  • trk
  • TRK
  • Trk
  • Trk-A
  • TRK1
  • TRKA
  • TrkA
  • trkA
  • trka
Alternatives
anti-Human TRKA antibody for Immunoprecipitation
Reactivity
Human, Mouse (Murine), Rat (Rattus)
380
198
167
2
2
Host
Rabbit
358
50
4
3
2
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
16
15
15
10
8
8
8
8
7
7
7
7
7
7
7
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
249
153
90
76
54
45
38
33
19
14
5
4
1
1
Supplier
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Immunogen Synthetic peptide surrounding amino acid 494 of human TrkA
Specificity The antibody detects 140 kDa TrkA. It does not cross-react with TrkB or TrkC.
Purification Affinity Chromatography
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background TrkA, the high affinity Nerve Growth Factor (NGF) receptor, autophosphorylates on tyrosine to activate multiple effectors. Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at these sites reflects Trk kinase activity.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
Gene ID 4914
NCBI Accession NP_001007793
UniProt P04629
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes Western blotting (0.5-4 μg/mL). Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, pH 7.2, containing 30 % Glycerol, 0.5 % BSA, 0.01 % Thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. For long-term storage, aliquot and freeze at -20 °C to -70 °C.
Supplier Images
 image for anti-TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (ABIN127050) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody
Background publications Segal, Greenberg: "Intracellular signaling pathways activated by neurotrophic factors." in: Annual review of neuroscience, Vol. 19, pp. 463-89, 1997 (PubMed).

Stephens, Loeb, Copeland, Pawson, Greene, Kaplan: "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses." in: Neuron, Vol. 12, Issue 3, pp. 691-705, 1994 (PubMed).