KIT antibody

Catalog No. ABIN133919

Product Details anti-KIT Antibody

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This KIT antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Mouse CD117 (c-kit)

Purification: Purified from ascitic fluid via Protein G Chromatography

Immunogen: IL-3 dependent mast cells derived from WB- +/+ mice . Fusion Partner: X63.653. Ag8 . Donor: Wistar spleen

Isotype: IgG1

Application Details

Application Notes: This product is suitable for use in flow cytometry, and has been reported to work in immunohistochemistry (frozen and polyester wax sections).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml

Buffer: Purified Ig buffered in PBS and 0.02% NaN (Purified from ascitic fluid via Protein G Chromatography)

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-KIT antibody (ABIN133919)

Iino, Horiguchi, Horiguchi: "Investigation of Novel c-Kit-expressing Smooth Muscle Cells in Murine Cecum." in: Acta histochemica et cytochemica, Vol. 53, Issue 2, pp. 11-19, (2020) (PubMed).

Ran, Chen, Sher, Wong, Murphy, Zhang, Li, Deniz, Sirota, Cao, Wang, Guan, Shukla, Li, Chramiec, Xie, Zheng, Koche, Antonescu, Chen, Chi: "FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor." in: Cancer discovery, Vol. 8, Issue 2, pp. 234-251, (2019) (PubMed).

Chen, Wang, Missinato, Park, Long, Liu, Zeng, Yates, Kim, Wang: "Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration." in: Science advances, Vol. 2, Issue 11, pp. e1600844, (2018) (PubMed).

Ran, Murphy, Sher, Cao, Wang, Walczak, Guan, Xie, Shukla, Zhan, Antonescu, Chen, Chi: "ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors." in: Cancer research, Vol. 77, Issue 14, pp. 3758-3765, (2017) (PubMed).

Ran, Sirota, Cao, Murphy, Chen, Shukla, Xie, Kaufmann, Gao, Zhu, Rossi, Wongvipat, Taguchi, Tap, Mellinghoff, Besmer, Antonescu, Chen, Chi: "Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth." in: Cancer discovery, Vol. 5, Issue 3, pp. 304-15, (2016) (PubMed).

Harris, Buac, Shakhova, Hakami, Wegner, Sommer, Pavan: "A dual role for SOX10 in the maintenance of the postnatal melanocyte lineage and the differentiation of melanocyte stem cell progenitors." in: PLoS genetics, Vol. 9, Issue 7, pp. e1003644, (2014) (PubMed).

Target Details for KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Alternative Name: CD117 (c-kit) (KIT Products)

Synonyms: C-Kit antibody, CD117 antibody, PBT antibody, SCFR antibody, Bs antibody, Fdc antibody, Gsfsco1 antibody, Gsfsco5 antibody, Gsfsow3 antibody, SCO1 antibody, SCO5 antibody, SOW3 antibody, Ssm antibody, Tr-kit antibody, W antibody, c-KIT antibody, c-kit antibody, MGF antibody, KIT antibody, C-KIT antibody, kit antibody, receptor antibody, sparse antibody, Xkl-1 antibody, kit-a antibody, kit-b antibody, kl1-A antibody, krk1 antibody, pbt antibody, scfr antibody, KIT proto-oncogene receptor tyrosine kinase antibody, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antibody, KIT proto-oncogene receptor tyrosine kinase S homeolog antibody, KIT antibody, Kit antibody, kita antibody, kit antibody, kit.S antibody

Background: Anti-mouse CD117 monoclonal antibody recognizes the receptor tyrosine kinase, c-kit. The ligand for this receptor is steel factor (stem cell factor), which exists in both soluble and membrane form. The interaction between steel factor and c-kit is essential for the development of hematopoietic, gonadal and pigment stem cells. c- kit positive cells are a subset of CD34+ hematopoietic precursor cells and it is expressed on 5-10% of total adult bone marrow cells. This product is suitable for use in flow cytometry, and has been reported to work in immunohistochemistry (frozen and polyester wax sections).

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity