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Details for Product No. ABIN135316

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) antibody (RPE)

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Antigen
Synonyms CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, Cd152, Ly-56, Ctla-4, sCTLA4, CTLA4
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Hamster
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 4 references available
Catalog no. ABIN135316
Quantity 0.1 mg
Price
236.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Clone 1B8
Isotype IgG
Characteristics The antibody detects: Mouse CD152/CTLA-4
Alternative Name CD152/CTLA-4
Background The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. However CD152 is thought to be a negative regulator of T cell activation and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer, and is relatively conserved among humans, mice and chickens.
Application Notes Working Dilution:
FACS: 03 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

In vitro functional studies

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.1 mg in 1.0 mL of PBS / NaN3 and a stabilizing agent.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze!
Protect conjugated products from light.

Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
Freeman, Lombard, Gimmi et al.: "CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 12, pp. 3795-801, 1993 (PubMed).

Walunas, Lenschow, Bakker et al.: "CTLA-4 can function as a negative regulator of T cell activation." in: Immunity, Vol. 1, Issue 5, pp. 405-13, 1995 (PubMed).

Leach, Krummel, Allison: "Enhancement of antitumor immunity by CTLA-4 blockade." in: Science (New York, N.Y.), Vol. 271, Issue 5256, pp. 1734-6, 1996 (PubMed).

Perkins, Wang, Donovan et al.: "Regulation of CTLA-4 expression during T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4154-9, 1996 (PubMed).

Alternatives for antigen "Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4)", type "Antibodies"
Hosts (104), (59), (54), (1), (1), (1)
Reactivities (106), (101), (76), (17), (17)
Applications (146), (58), (53), (30), (21), (20), (12), (12), (10), (9), (6), (2), (1), (1), (1), (1)
Conjugates (29), (26), (20), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (33), (5), (5), (4), (2), (2), (2), (2), (1), (1)
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