SOX10 antibody
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- Target See all SOX10 Antibodies
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SOX10 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human SOX10
- Isotype
- IgG
- Top Product
- Discover our top product SOX10 Primary Antibody
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- Application Notes
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WB: 1:100-1000, IHC-P: 1:100-500, IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
- Alternative Name
- Sox10 (SOX10 Products)
- Synonyms
- DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody
- Background
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Synonyms: DOM, MGC15649, SOX 10, SOX10, SOX10_HUMAN, SRY sex determining region Y box 10, SRY box containing gene 10, SRY related HMG box gene 10, Transcription factor SOX 10, Transcription factor SOX-10, WS4.
Background: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. Involvement in disease, Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E) . WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C), also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).Defects in SOX10 are a cause of Yemenite deaf-blind hypopigmentation syndrome (YDBHS) . YDBHS consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. Another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome.
- Gene ID
- 6663
- Pathways
- Chromatin Binding
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