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MDM4-binding Protein antibody (pSer367)
MDM4
Reactivity: Human, Mouse
WB
Host: Mouse
Monoclonal
#15
unconjugated
Product Details anti-MDM4-binding Protein Antibody
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Target
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MDM4-binding Protein (MDM4)
(Mdm4-binding Protein (MDM4))
Binding Specificity
All epitopes for MDM4-binding Protein antibodies
pSer367
Reactivity
All reactivities for MDM4-binding Protein antibodies
Human, Mouse
Host
All hosts for MDM4-binding Protein antibodies
Mouse
Clonality
All clonalities for MDM4-binding Protein antibodies
Monoclonal
Conjugate
All conjugates for MDM4-binding Protein antibodies
This MDM4-binding Protein antibody is un-conjugated
Application
All applications for MDM4-binding Protein antibodies
Western Blotting (WB)
Specificity
This antibody specifically recognizes MdmX protein phosphorylated at Ser367.
Cross-Reactivity (Details)
Species reactivity (tested):Human, Mouse
Clone
#15
Isotype
IgG2b
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Discover our top product MDM4 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative
Without preservative
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Upon receipt, store (in aliqouts) at -20 °C.
Target Details for MDM4-binding Protein
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Target
MDM4-binding Protein (MDM4)
(Mdm4-binding Protein (MDM4))
Alternative Name
MDM4 (MDM4 Products )
Synonyms
mdmx antibody, HDMX antibody, MDMX antibody, MRP1 antibody, wu:fa09h09 antibody, wu:fi33d10 antibody, 4933417N07Rik antibody, AA414968 antibody, AL023055 antibody, AU018793 antibody, AU021806 antibody, C85810 antibody, Mdmx antibody, MDM4, p53 regulator S homeolog antibody, MDM4, p53 regulator antibody, transformed mouse 3T3 cell double minute 4 antibody, mdm4.S antibody, MDM4 antibody, Mdm4 antibody, mdm4 antibody
Background
MdmX (Mdm4, HdmX) inhibits p53-and p73-dependent cell cycle arrest and apoptosis by binding to the transcription activation domains of these proteins. MdmX consists of 490 amino acids with the molecular weight of 54,864 and contains a RIING-finger domain and a nuclear transport signal. It is known that the protein migrates aberrantly in SDS-PAGE at the position of an 80 kDa protein. MdmX is phosphorylated at Ser367 by Chk2 kinase downstream of ATM in response to DNA damage, and as the result, it binds to 14-3-3 and is transported into nucleus where it is degraded by Mdm2. This process activates the p53 functions (Ref 1, 2, 3).Synonyms: Double minute 4 protein, MDM-4, MDMX, Mdm2-like p53-binding protein, p53-binding protein Mdm4
Gene ID
4194
NCBI Accession
NP_002384
UniProt
O15151
Pathways
Cell Division Cycle
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