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CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 30-57)

Details for Product anti-CDK1 Antibody No. ABIN1449303, Supplier: Log in to see
Antigen
Alternatives
anti-Human CDK1 antibody for Immunocytochemistry
Epitope
AA 30-57, AA 42-49
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69
46
33
32
28
20
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15
14
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14
14
14
8
6
5
5
5
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3
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3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
Reactivity
Human, Mouse (Murine), Rabbit, Rat (Rattus)
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256
227
28
25
23
17
10
9
5
5
5
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4
2
2
1
1
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1
1
1
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Host
Mouse
499
145
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK1 antibody is un-conjugated
27
23
20
16
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15
6
5
5
5
5
5
5
5
5
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
515
236
163
98
92
73
57
33
32
14
10
10
7
6
6
2
1
1
1
Supplier
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Immunogen KLH conjugated Cdc2 peptide (30-57 aa)
Sequence EGVPSTAI
Clone 5F6
Isotype IgG2b
Specificity This antibody reacts with Cdc2. The epitope of 5F6 exists between amino acids 42 and 49 of Cdc2 (EGVPSTAI).
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat, Hamster.
Purification Protein A agarose
Alternative Name CDK1 (CDK1 Antibody Abstract)
Background Cell division cycle 2 (Cdc2) also named p34cdc2 or Cdk1 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor that induces entry into mitosis and is universal among eukaryotes. In the fission yeast Schizosaccharomyces pombe, the gene Cdc2 is responsible for controlling the transition from G1 phase to the S phase and from the G2 phase to the M phase of the cell cycle.Synonyms: CDC2, CDC28A, CDK1, CDKN1, Cell division control protein 2 homolog, Cell division protein kinase 1, Cyclin-dependent kinase 1, P34CDC2, p34 protein kinase
Gene ID 983
NCBI Accession NP_001777
UniProt P06493
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 30-57) (ABIN1449303) anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 30-57), (AA 42-49) antibody
Immunohistochemistry (IHC) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 30-57) (ABIN1449303) anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 30-57), (AA 42-49) antibody (Image 2)
Western Blotting (WB) image for anti-CDK1 antibody (Cyclin-Dependent Kinase 1) (AA 30-57) (ABIN1449303) anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 30-57), (AA 42-49) antibody (Image 3)
Background publications Wakasugi, Kobayashi, Tamaki et al.: "Analysis of phosphorylation of pRB and its regulatory proteins in breast cancer." in: Journal of clinical pathology, Vol. 50, Issue 5, pp. 407-12, 1997 (PubMed).

Reagan: "Expression cloning of an insect diuretic hormone receptor. A member of the calcitonin/secretin receptor family." in: The Journal of biological chemistry, Vol. 269, Issue 1, pp. 9-12, 1994 (PubMed).

Pines, Hunter: "Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2." in: Cell, Vol. 58, Issue 5, pp. 833-46, 1989 (PubMed).

Lehner, OFarrell: "Expression and function of Drosophila cyclin A during embryonic cell cycle progression." in: Cell, Vol. 56, Issue 6, pp. 957-68, 1989 (PubMed).

Khorana: "Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function." in: The Journal of biological chemistry, Vol. 267, Issue 1, pp. 1-4, 1992 (PubMed).