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SARM1 antibody (Sterile alpha and TIR Motif Containing 1) (N-Term)

Details for Product anti-SARM1 Antibody No. ABIN1449950, Supplier: Log in to see
Antigen
  • A830091I15Rik
  • C78606
  • MyD885
  • Sarm
  • MyD88-5
  • SAMD2
  • SARM
  • sterile alpha and TIR motif containing 1
  • sterile alpha and HEAT/Armadillo motif containing 1
  • SARM1
  • LOC100349344
  • Sarm1
  • sarm1
Alternatives
anti-Human SARM1 antibody for Immunofluorescence
Epitope
N-Term
17
15
5
4
2
2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
55
32
18
Host
Rabbit
44
11
Clonality
Polyclonal
Conjugate
This SARM1 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
30
15
13
11
10
9
8
7
1
1
Options
Supplier
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Immunogen 16 amino acid synthetic peptide near the amino terminus of Human SARM
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Affinity chromatography purified via peptide column
Alternative Name SARM1 (SARM1 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.Synonyms: KIAA0524, SAM domain-containing protein 2, SAMD2, SARM, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2
Gene ID 23098
NCBI Accession NP_055892
Pathways TLR Signaling, Activation of Innate immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-SARM1 antibody (Sterile alpha and TIR Motif Containing 1) (N-Term) (ABIN1449950) Western blot analysis of SARM in human kidney tissue lysate with SARM Antibody  at (A...
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).