HPTP antibody, HPTPD antibody, HPTPDELTA antibody, PTPD antibody, RPTPDELTA antibody, 1110002J03Rik antibody, 3000002J10Rik antibody, B230219D21Rik antibody, R-PTP-delta antibody, ptprd antibody, zgc:165626 antibody, ptpdelta antibody, rptpdelta antibody, xptp-d antibody, protein tyrosine phosphatase, receptor type D antibody, protein tyrosine phosphatase, receptor type, D antibody, receptor-type tyrosine-protein phosphatase delta antibody, protein tyrosine phosphatase, receptor type, D, b antibody, protein tyrosine phosphatase, receptor type D S homeolog antibody, PTPRD antibody, Ptprd antibody, LOC100155429 antibody, ptprdb antibody, ptprd.S antibody
Background
PTPRD (Protein tyrosine phosphatase receptor type D) is a member of the protein tyrosine phosphatase (PTP) family that plays diverse roles during development including cell growth, differentiation, mitotic cycle and oncogenic transformation. PTPRD contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The extracellular region of PTPRD is composed of three Ig-like and eight fibronectin type III-like domains (1,3). PTPRD interacts with PPFIA1-3 and is a tumor suppressor on chromosome 9p that is involved in the development of glioblastoma multiforme (GBMs) and multiple human cancers.Synonyms: Protein-tyrosine phosphatase delta, R-PTP-delta, Receptor-type tyrosine-protein phosphatase delta