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PYCARD antibody (AA 50-195)

PYCARD Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3021617
  • Target See all PYCARD Antibodies
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Binding Specificity
    • 10
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-195
    Reactivity
    • 56
    • 10
    • 9
    • 1
    • 1
    • 1
    Human
    Host
    • 47
    • 7
    • 3
    Rabbit
    Clonality
    • 46
    • 11
    Polyclonal
    Conjugate
    • 32
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PYCARD antibody is un-conjugated
    Application
    • 39
    • 23
    • 15
    • 12
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    LDLTDKLVSF YLETYGAELT ANVLRDMGLQ EMAGQLQAAT HQGSGAAPAG IQAPPQSAAK PGLHFIDQHR AALIARVTNV EWLLDALYGK VLTDEQYQAV RAEPTNPSKM RKLFSFTPAW NWTCKDLLLQ ALRESQSYLV EDLERS
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 50-195 of human ASC / TMS1 (NP_037390.2).
    Isotype
    IgG
    Top Product
    Discover our top product PYCARD Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze / thaw cycles
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Deng, Zou, Xiong, Wang, Engelhardt, Ye, Yan, Qiu: "Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis." in: Journal of virology, Vol. 91, Issue 24, (2017) (PubMed).

  • Target
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Alternative Name
    PYCARD (PYCARD Products)
    Synonyms
    ASC antibody, CARD5 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, 9130417A21Rik antibody, Asc antibody, TNS1 antibody, masc antibody, asc1 antibody, zAsc antibody, zgc:109874 antibody, PYD and CARD domain containing antibody, PYCARD antibody, Pycard antibody, pycard antibody
    Background
    This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.,PYCARD,ASC,CARD5,TMS,TMS-1,TMS1,PYD and CARD domain containing,ASC / TMS1,Cancer,Tumor biomarkers,Cell Biology & Developmental Biology,Apoptosis,Caspases,PYCARD
    Molecular Weight
    15 kDa/19 kDa/21 kDa
    Gene ID
    29108
    UniProt
    Q9ULZ3
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome
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