FLT1 antibody (Soluble)
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- Target See all FLT1 Antibodies
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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Binding Specificity
- Soluble
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FLT1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.
- Characteristics
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Chromosomal location: 13q12
Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-1/Flt-1 (CNKKAVFSRISKFKSTRNDSTTQSNVKH). - Purification
- Anti-human soluble VEGFR-1/Flt-1 was purified by affinity chromatography with immobilized Protein A.
- Isotype
- IgG
- Top Product
- Discover our top product FLT1 Primary Antibody
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- Application Notes
- Western Blot: use 1-5 µg/mL
- Comment
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Rabbit IG Polyclonal Antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS
- Handling Advice
- Centrifuge vial prior to opening.
- Storage
- -20 °C
- Storage Comment
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- Expiry Date
- 6 months
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- Target
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
- Alternative Name
- VEGFR-1/Flt-1 (FLT1 Products)
- Synonyms
- FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody
- Background
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Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Synonyms: soluble vascular endothelial growth factor receptor-1, soluble FLT1, soluble FLT, soluble VEGF receptor 1 - NCBI Accession
- NM_001159920, NP_001153392
- UniProt
- P17948
- Pathways
- RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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