Endoglin antibody
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- Target See all Endoglin (ENG) Antibodies
- Endoglin (ENG)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Endoglin antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), ELISA
- Specificity
- Recombinant human sCD105/Endoglin
- Characteristics
- Chromosomal location: 9q33-q34.1
- Isotype
- IgG
- Top Product
- Discover our top product ENG Primary Antibody
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- Application Notes
- Western Blot: use 1-5 µg/mL
- Comment
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Rabbit IG Polyclonal Antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- PBS
- Handling Advice
- Centrifuge vial prior to opening.
- Storage
- -20 °C
- Storage Comment
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- Expiry Date
- 6 months
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Heterogeneity of stromal cells in the human splenic white pulp. Fibroblastic reticulum cells, follicular dendritic cells and a third superficial stromal cell type." in: Immunology, Vol. 143, Issue 3, pp. 462-77, (2014) (PubMed).
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Heterogeneity of stromal cells in the human splenic white pulp. Fibroblastic reticulum cells, follicular dendritic cells and a third superficial stromal cell type." in: Immunology, Vol. 143, Issue 3, pp. 462-77, (2014) (PubMed).
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- Target
- Endoglin (ENG)
- Alternative Name
- CD105/Endoglin (ENG Products)
- Synonyms
- ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
- Background
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Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Synonyms: Endoglin, END, ORW, HHT1, ORW1, CD105 - NCBI Accession
- NP_000109, NM_000118
- UniProt
- P17813
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