ATM
Reactivity: Human
IF, DB
Host: Rabbit
Polyclonal
RB8121
unconjugated
Application Notes
Working dilution: Optimal dilution should be determined by the end user. The following are guidelines only: WB1:500 - 1:3000 IHC-P5 μg/mL IP1 - 10 μg/mL.
Restrictions
For Research Use only
Buffer
PBS, pH 7.4
Handling Advice
Dilute in PBS or medium that is identical to that used in the assay system.
Storage
-20 °C/-80 °C
Storage Comment
Stable for at least one year at -20°C or -70°C. Avoid multiple freeze-thaw cycles.
ATM is a 370 kD nuclear phosphoprotein,which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.