Sirtuin 2 (SIRT2) (C-Term) antibody

Details for Product No. ABIN182553
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Antigen
Synonyms SIR2, SIR2L, SIR2L2, Sir2l, 5730427M03Rik, zgc:55966, zgc:77003, wu:fb57d05, CG5085, D.mel2, Dmel\\CG5085, SIRT2, dSIRT2, sir2, Sirt2, BmSirt2, AtSRT2, SIRTUIN 2, T2K12.8, sirtuin 2
Epitope
C-Term
(24), (13), (5), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Pig (Porcine), Zebrafish (Danio rerio), Human
(79), (55), (50), (4), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(85), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(77), (49), (27), (18), (10), (6), (4), (3), (3), (3), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN182553
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the C terminal of human SIRT2
Sequence DVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS GAGVPNPSTS
Predicted Reactivity Human : 100 %, Bovine : 90 %, Guinea pig : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 90 %, Dog : 80 %, Rabbit : 70 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against SIRT2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SIRT2
Background SIRT2 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.
Molecular Weight 40 kDa
Gene ID 22933
NCBI Accession NM_030593, NP_085096
UniProt Q8IXJ6
Research Area Chromatin and Nuclear Signaling, Cytoskeleton, Proteases
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 352 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Borra, Langer, Slama et al.: "Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases." in: Biochemistry, Vol. 43, Issue 30, pp. 9877-87, 2004 (PubMed).

Hosts (85), (7)
Reactivities (79), (55), (50), (4), (2), (2), (1), (1), (1), (1), (1)
Applications (77), (49), (27), (18), (10), (6), (4), (3), (3), (3), (1), (1), (1)
Conjugates (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (13), (5), (3), (2), (1), (1), (1), (1), (1), (1)
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