Sirtuin 1 (SIRT1) (N-Term) antibody

Details for Product No. ABIN182555
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Antigen
Synonyms sirtuin 1, AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha, sir2l1, sirtuin, SIR2
Epitope
N-Term
(17), (17), (13), (13), (12), (10), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Human
(156), (88), (42), (26), (25), (14), (13), (6), (1), (1)
Host
Rabbit
(119), (31), (8), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(120), (65), (40), (33), (31), (21), (21), (12), (7), (6), (1), (1), (1)
Pubmed 2 references available
Quantity 100 µg
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Catalog No. ABIN182555
229.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human SIRT1
Sequence PETIPPPELD DMTLWQIVIN ILSEPPKRKK RKDINTIEDA VKLLQECKKI
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, African clawed frog : 90 %, Chicken : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against SIRT1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name SIRT1
Background SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.
Molecular Weight 82 kDa
Gene ID 23411
NCBI Accession NP_036370, NM_012238
UniProt Q96EB6
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 747 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Product cited in: Anavekar, Mirza, Skali et al.: "Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial performance index--Survival and Ventricular Enlargement (SAVE) experience." in: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Vol. 19, Issue 1, pp. 28-33, 2006 (PubMed).

Background publications Solomon, Pasupuleti, Xu et al.: "Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 28-38, 2005 (PubMed).

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