anti-Aprataxin antibody (APTX) (N-Term)

Details for Product anti-APTX Antibody No. ABIN182697, Supplier: Login to see New
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Antigen
Alternatives
Epitope
N-Term
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Xenopus laevis
(46), (22), (22), (3), (3), (2), (2), (1)
Host
Rabbit
(38), (6), (2)
Clonality
Polyclonal
Conjugate
This Aprataxin antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(31), (14), (12), (11), (4), (4), (2), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human APTX
Sequence MMRVCWLVRQ DSRHQRIRLP HLEAVVIGRG PETKITDKKC SRQQVQLKAE
Predicted Reactivity Human : 100 %, Horse : 90 %, Mouse : 90 %, Rat : 90 %, African clawed frog : 80 %, Guinea pig : 80 %, Pig : 80 %, Dog : 80 %
Characteristics This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name APTX (APTX Antibody Abstract)
Background APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Molecular Weight 38 kDa
Gene ID 54840
NCBI Accession NM_175073, NP_778243
UniProt Q6JV85
Pathways DNA Damage Repair
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 342 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Aprataxin antibody (APTX) (N-Term) (ABIN182697) WB Suggested Anti-APTX Antibody Titration: 1.25ug/ml
ELISA Titer: 1:...
Western Blotting (WB) image for anti-Aprataxin antibody (APTX) (N-Term) (ABIN182697) WB Suggested Anti-APTX
Antibody Titration: 1.25 µg/mL ELISA Titer: 1:1562500 <...
Background publications Ahnesorg, Smith, Jackson: "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining." in: Cell, Vol. 124, Issue 2, pp. 301-13, 2006 (PubMed).

Catalog No. ABIN182697
$229.00
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