This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RNASE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human RNASE1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
DAlessio: "It takes two to flirt with a dimeric RNase." in: Biopolymers, Vol. 91, Issue 12, pp. 989-94, (2009) (PubMed).
Kövér, Bruix, Santoro, Batta, Laurents, Rico: "The solution structure and dynamics of human pancreatic ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition." in: Journal of molecular biology, Vol. 379, Issue 5, pp. 953-65, (2008) (PubMed).
Cybulski, Wokołorczyk, Jakubowska, Gliniewicz, Sikorski, Huzarski, Debniak, Narod, Lubiński: "DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland." in: Urologia internationalis, Vol. 79, Issue 1, pp. 44-9, (2007) (PubMed).
Target
RNASE1
(Ribonuclease, RNase A Family, 1 (Pancreatic) (RNASE1))
RNASE1 antibody, RNS1 antibody, ATRNS1 antibody, RIBONUCLEASE 1 antibody, T17M13.16 antibody, T17M13_16 antibody, ribonuclease 1 antibody, RIB1 antibody, AI574248 antibody, Rib-1 antibody, Rib1 antibody, SRN antibody, ribonuclease A family member 1, pancreatic antibody, ribonuclease pancreatic-like antibody, ribonuclease A family member k6 antibody, Ribonuclease 1 antibody, ribonuclease 1 antibody, ribonuclease, RNase A family, 1 (pancreatic) antibody, ribonuclease pancreatic antibody, RNASE1 antibody, LOC475395 antibody, RNASE6 antibody, Rnase1 antibody, RNS1 antibody, LOC101113761 antibody
Background
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].