DHX58 antibody (C-Term)

Catalog No. ABIN1886910

Product Details anti-DHX58 Antibody

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHX58 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: 12 amino acid peptide from near the carboxy terminus of human LGP2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DHX58

Target: DHX58 (DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))

Alternative Name: LGP2 (DHX58 Products)

Synonyms: MGC82787 antibody, DHX58 antibody, lgp2 antibody, D11LGP2 antibody, D11lgp2e antibody, LGP2 antibody, RLR-3 antibody, B430001I08Rik antibody, D11Lgp2e antibody, LPG2 antibody, Lgp2 antibody, RGD1310093 antibody, DEXH-box helicase 58 L homeolog antibody, DExH-box helicase 58 antibody, probable ATP-dependent RNA helicase DHX58 antibody, DEXH (Asp-Glu-X-His) box polypeptide 58 antibody, DEXH-box helicase 58 antibody, dhx58.L antibody, DHX58 antibody, dhx58 antibody, LOC100566102 antibody, Dhx58 antibody

Background: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms.The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids.Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm.A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain.It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling.At least four isoforms of LGP2 are known to exist.
Synonyms: DHX58, likely ortholog of mouse D11lgp2