OTUD5 antibody (C-Term)

Catalog No. ABIN1886937

Product Details anti-OTUD5 Antibody

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the carboxy terminus of the human OTUD5.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for OTUD5

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Alternative Name: OTUD5 (OTUD5 Products)

Synonyms: DUBA antibody, AA407879 antibody, AI553596 antibody, BB114028 antibody, DXImx46e antibody, Sfc7 antibody, otud5 antibody, si:bz30i22.1 antibody, si:rp71-30i22.1 antibody, zgc:154072 antibody, wu:fi28a06 antibody, zgc:100839 antibody, OTU deubiquitinase 5 antibody, OTU domain containing 5 antibody, OTU deubiquitinase 5a antibody, OTU deubiquitinase 5 S homeolog antibody, OTU deubiquitinase 5 L homeolog antibody, OTU deubiquitinase 5b antibody, OTUD5 antibody, Otud5 antibody, otud5a antibody, otud5.S antibody, otud5.L antibody, otud5b antibody

Background: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily.The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein.Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses.It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus.Multiple isoforms of OTUD5 are known to exist.
Synonyms: OTU domain-containing protein 5, Deubiquitinating enzyme A, DUBA