NLRP1 antibody (C-Term)

Catalog No. ABIN1887358

Product Details anti-NLRP1 Antibody

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Immunoaffinity chromatography purified IgG

Immunogen: Peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: NALP1 (NLRP1 Products)

Synonyms: CARD7 antibody, CIDED antibody, CLR17.1 antibody, DEFCAP antibody, DEFCAP-L/S antibody, NAC antibody, NALP1 antibody, PP1044 antibody, SLEV1 antibody, VAMAS1 antibody, NLR family pyrin domain containing 1 antibody, NLRP1 antibody, Nlrp1 antibody

Background: NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli.It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR).This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1.Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis.NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli.Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.
Synonyms: CARD7, DEFCAP, NACHT domain- leucine-rich-repeat and PYD-containing protein 1

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome