Retinoblastoma Binding Protein 8 antibody (Center)

Catalog No. ABIN1887524

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the center of human RBBP8.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8 (RBBP8 Products)

Synonyms: COM1 antibody, CTIP antibody, JWDS antibody, RIM antibody, SAE2 antibody, SCKL2 antibody, 9930104E21Rik antibody, CtIP antibody, RBBP-8 antibody, RGD1308872 antibody, RBBP8 antibody, DKFZp469K0714 antibody, RB binding protein 8, endonuclease antibody, retinoblastoma binding protein 8, endonuclease antibody, retinoblastoma binding protein 8 L homeolog antibody, retinoblastoma binding protein 8 antibody, RBBP8 antibody, Rbbp8 antibody, rbbp8.L antibody, rbbp8 antibody

Background: RBBP8, also known as CtBP (carboxy-terminal binding protein) interacting protein (CTIP), was characterized for its role in transcription as a cofactor for the transcriptional repressor CtBP, and also as a binding partner for other proteins including the cell cycle regulators retinoblastoma protein (Rb) and breast cancer 1 (BRCA1).It is ubiquitously expressed and localizes to the nucleus.RBBP8 is thought to modulate the functions in cell proliferation, transcriptional regulation and DNA repair.RBBP8 also plays a central role in the cell cycle checkpoint response to DNA double-stranded breaks (DSBs), with new evidence demonstrating that it controls the choice of DSB repair pathway.
Synonyms: Retinoblastoma-binding protein 8, CTIP, CtBP-interacting protein, RIM

NCBI Accession: NP_976037

Pathways: Cell Division Cycle, DNA Damage Repair