RNASEH2A antibody (Center)

Catalog No. ABIN1887662

Product Details anti-RNASEH2A Antibody

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Binding Specificity: Center

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human RNAse H2A.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for RNASEH2A

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Alternative Name: RNAse H2A (RNASEH2A Products)

Synonyms: 2400006P09Rik antibody, RNASEHI antibody, RNHIA antibody, RNHL antibody, zgc:56307 antibody, AGS4 antibody, JUNB antibody, ribonuclease H2 subunit A antibody, ribonuclease H2, large subunit antibody, ribonuclease H2, subunit A antibody, ribonuclease H2 subunit A L homeolog antibody, rnaseh2a antibody, RNASEH2A antibody, Rnaseh2a antibody, rnaseh2a.L antibody

Background: Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids.The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair.RNAse H2 is made up of three subunits, all three are required for RNAse activity.Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid.Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
Synonyms: Rnse H2A, Ribonuclease H2 subunit A, RNAse HI large subunit, Aicadi-Goutieres, syndrome 4 protein, AGS4

UniProt: O75792