TNFAIP3 antibody (Center)

Catalog No. ABIN1887667

Product Details anti-TNFAIP3 Antibody

Target: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFAIP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human TNFAIP3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TNFAIP3

Target: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Alternative Name: TNFAIP3 (TNFAIP3 Products)

Synonyms: tnfaip3 antibody, MGC82339 antibody, TNFAIP3 antibody, A20 antibody, OTUD7C antibody, TNFA1P2 antibody, Tnfip3 antibody, TNF alpha induced protein 3 antibody, TNF alpha induced protein 3 S homeolog antibody, tumor necrosis factor, alpha-induced protein 3 antibody, TNFAIP3 antibody, tnfaip3.S antibody, Tnfaip3 antibody

Background: TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas.Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas.TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-alpha, inhibiting NF-kappaB-dependent gene expression, and protecting cells from TNF-alpha-cytotoxicity.Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens.At least two isoforms of TNFAIP3 are known to exist.
Synonyms: TNFAIP3 (IN), Tumor necrosis factor alpha-induced protein 3, A20, OTUD7C, TNFA1P2

UniProt: Q60769

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response