KDM3B antibody (Center)

Catalog No. ABIN1887725

Product Details anti-KDM3B Antibody

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): This antibody will not cross-react with JMJD1A or JMJD1C.

Purification: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide from near the center of human JMJD1B.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for KDM3B

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Alternative Name: JMJD1B (KDM3B Products)

Synonyms: KDM3B antibody, JMJD1B antibody, 5830462I21Rik antibody, JHDM2B antibody, Jmjd1b antibody, mKIAA1082 antibody, 5qNCA antibody, C5orf7 antibody, NET22 antibody, lysine demethylase 3B antibody, lysine (K)-specific demethylase 3B antibody, lysine-specific demethylase 3B antibody, KDM3B lysine (K)-specific demethylase 3B antibody, KDM3B antibody, LOC100540242 antibody, kdm3b antibody, Kdm3b antibody

Background: The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene.Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues.The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor.In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated.At least three isoforms of JMJD1B are known to exist.
Synonyms: 5qNCA, Lysine-specific demethylase 3B, KDM3B

Pathways: Warburg Effect