Transportin 3 antibody (N-Term)

Catalog No. ABIN1888081

Product Details anti-Transportin 3 Antibody

Target: Transportin 3 (TNPO3)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transportin 3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the amino terminus of human TNPO3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Transportin 3

Target: Transportin 3 (TNPO3)

Alternative Name: TNPO3 (TNPO3 Products)

Synonyms: zgc:55409 antibody, tnpo3 antibody, MGC82948 antibody, TNPO3 antibody, DKFZp459J2330 antibody, IPO12 antibody, MTR10A antibody, TRN-SR antibody, TRN-SR2 antibody, TRNSR antibody, 5730544L10Rik antibody, C430013M08Rik antibody, C81142 antibody, D6Ertd313e antibody, Trn-SR antibody, mKIAA4133 antibody, transportin 3 antibody, transportin 3 S homeolog antibody, transportin-SR antibody, tnpo3 antibody, TNPO3 antibody, tnpo3.S antibody, Bm1_43850 antibody, LOAG_04608 antibody, Tnpo3 antibody

Background: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins.Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated.More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment.At least three isoforms of TNPO3 are known to exist.
Synonyms: Transportin-3, Importin-12, IPO12, TRNSR, MTR10A, TRN-SR

Pathways: Protein targeting to Nucleus