SNCA antibody (Synuclein, alpha)

Details for Product anti-SNCA Antibody No. ABIN236423, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Alternatives
anti-Human SNCA antibody for Cytometry by Time of Flight
Reactivity
Human
705
391
379
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10
7
4
2
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2
1
1
1
Host
Mouse
406
280
34
10
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This SNCA antibody is un-conjugated
32
31
26
12
12
10
9
6
6
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4
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
559
324
193
191
124
103
79
78
27
26
21
17
13
10
7
3
2
2
2
1
Options
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Immunogen Purified E. coli produced human alpha-synuclein
Clone 4D6
Isotype IgG1
Specificity Reacts well with alpha-synuclein in Western blots and frozen and formalin-fixed/paraffin-embedded tissue sections. Recognizes human alpha-synuclein. Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.
Characteristics MAb to Synuclein Alpha, Monoclonal antibody to Human Synuclein alpha, Tissue culture supernatant
Purification Protein A column Chromatography. Cell culture
Alternative Name Synuclein alpha (SNCA Antibody Abstract)
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes Western/Dot blot (1:100 - 1:10.000) ELISA Immunohistochemistry: (1:100 - 1:1.000) frozen and formalin-fixed paraffin-embedded tissues (No formic acid, enzyme or HIER required). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage -20 °C
Storage Comment Store at -20 °C.
Background publications Conway, Lee, Rochet, Ding, Harper, Williamson, Lansbury: "Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 42-5, 2001 (PubMed).

Kahle, Neumann, Ozmen, Haass: "Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 33-41, 2001 (PubMed).

McKeith: "Clinical Lewy body syndromes." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 1-8, 2001 (PubMed).

Polymeropoulos: "Genetics of Parkinson's disease." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 28-32, 2001 (PubMed).

Spillantini, Goedert: "The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 16-27, 2001 (PubMed).

Trojanowski, Lee: "\' of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders." in: Annals of the New York Academy of Sciences, Vol. 924, pp. 62-7, 2001 (PubMed).

Braak, Braak: "Pathoanatomy of Parkinson's disease." in: Journal of neurology, Vol. 247 Suppl 2, pp. II3-10, 2000 (PubMed).