The antibody detects endogenous level of GTPase Activating Protein only when phosphorylated at serine 387.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
GTPase Activating Protein (phospho Ser387) antibody was raised against a peptide sequence around phosphorylation site of serine 387 (R-I-S (p)-G-C) derived from Human GTPase Activating Protein.
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation.