PAI1 antibody

Catalog No. ABIN264029

The Mouse Monoclonal anti-PAI1 antibody is suitable to detect PAI1 in samples from Human. It has been validated for EIA.

Quick Overview for PAI1 antibody (ABIN264029)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAI1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 1-79769313486232E-308

Product Details anti-PAI1 Antibody

Characteristics: Synonyms: Serpin E1, PLANH1, Plasminogen Activator Inhibitor 1, PAI-1, PAI, Endothelial plasminogenactivator inhibitor

Purification: Protein A chromatography

Purity: > 98 % pure (SDS-PAGE)

Immunogen: Recombinant human PAI

Isotype: IgG

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 2.5mg/mL (OD280nm, E0.1% = 1.36)

Buffer: 0.05 M Sodium phosphate, 0.5 M Sodium chloride, 1 mM EDTA, pH 6.6

Storage: -80 °C

Storage Comment: Store the antibody at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Alternative Name: SERPINE1 / PAI1

Background: PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1

UniProt: P05121

Pathways: p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration