Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) antibody

Details for Product No. ABIN264097
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Antigen
Synonyms NACP, alphaSYN, PARK1, PARK4, PD1
Reactivity
Human
(383), (165), (141), (92), (89), (78), (24), (24), (3), (1), (1)
Host
Mouse
(281), (94), (15), (10), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (11), (11), (8), (8), (8), (8), (8), (8), (8), (8)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(267), (113), (82), (80), (74), (67), (29), (21), (16), (6), (3), (2), (1), (1)
Pubmed 9 references available
Quantity 0.2 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264097
1,171.50 $
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Immunogen Purified E. coli produced Human alpha-synuclein
Clone 4D6
Isotype IgG1
Characteristics Synonyms: NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloidprecursor
Purification Protein A Chromatography.
Alternative Name Alpha-Synuclein / SNCA
Background Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed oftruncated and phosphorylated intermediate neurofilament proteins, alpha synuclein,ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20kDa) are smallhighly conserved proteins in vertebrates. The synuclein family includes alpha and betasynucleins and loosely related gamma-synuclein and synoretin. The expression isabundant in neurons and typically localized at presynaptic terminals.
UniProt P37840
Research Area Neurology
Application Notes ELISA. Western/Dot Blot: 1/100-1/10,000. Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Embedded Tissues: 1/100-1/1,000 (No formic acid, enzyme or HIER required). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS without preservatives.
Preservative Without preservative
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Clayton, George: "Synucleins in synaptic plasticity and neurodegenerative disorders." in: Journal of neuroscience research, Vol. 58, Issue 1, pp. 120-9, 1999 (PubMed).

Schulz, Dichgans: "Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration?" in: Current opinion in neurology, Vol. 12, Issue 4, pp. 433-9, 1999 (PubMed).

Munoz: "Stains for the differential diagnosis of degenerative dementias." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 74, Issue 6, pp. 311-20, 2000 (PubMed).

Spillantini, Goedert: "The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 16-27, 2001 (PubMed).

Polymeropoulos: "Genetics of Parkinson's disease." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 28-32, 2001 (PubMed).

Kahle, Neumann, Ozmen et al.: "Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 33-41, 2001 (PubMed).

Conway, Lee, Rochet et al.: "Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 42-5, 2001 (PubMed).

Trojanowski, Lee: "\" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders." in: Annals of the New York Academy of Sciences, Vol. 924, pp. 62-7, 2001 (PubMed).

Lücking, Brice: "Alpha-synuclein and Parkinson's disease." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 13-14, pp. 1894-908, 2001 (PubMed).

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