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CSF1R antibody (Alexa Fluor 488)
CSF1R
Reactivity: Mouse
FACS, ELISA (Detection)
Host: Rat
Monoclonal
AFS98
Alexa Fluor 488
Product Details anti-CSF1R Antibody (Alexa Fluor 488)
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Target
See all CSF1R Antibodies
CSF1R
(Colony Stimulating Factor 1 Receptor (CSF1R))
Reactivity
All reactivities for CSF1R antibodies
Mouse
Host
All hosts for CSF1R antibodies
Rat
Clonality
All clonalities for CSF1R antibodies
Monoclonal
Conjugate
All conjugates for CSF1R antibodies
This CSF1R antibody is conjugated to Alexa Fluor 488
Application
All applications for CSF1R antibodies
Flow Cytometry (FACS), ELISA (Detection)
Purification
The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.
Clone
AFS98
Isotype
IgG2a kappa
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Discover our top product CSF1R Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for CSF1R
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Target
CSF1R
(Colony Stimulating Factor 1 Receptor (CSF1R))
Alternative Name
CD115 (CSF1R Products )
Synonyms
AI323359 antibody, CD115 antibody, CSF-1R antibody, Csfmr antibody, Fim-2 antibody, Fms antibody, M-CSF-R antibody, M-CSFR antibody, C-FMS antibody, CSFR antibody, FIM2 antibody, FMS antibody, HDLS antibody, PDGFRB antibody, MGC89146 antibody, CSF-1-R antibody, c-fms antibody, mrfms antibody, CSF1 antibody, M-CSF antibody, csf1r antibody, fms antibody, panther antibody, colony stimulating factor 1 receptor antibody, macrophage colony-stimulating factor receptor antibody, colony stimulating factor 1 receptor, a antibody, Csf1r antibody, CSF1R antibody, m-csfr antibody, csf1r antibody, csf1ra antibody
Background
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Pathways
RTK Signaling , Inositol Metabolic Process , Cell-Cell Junction Organization
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