CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Reactivity
Mouse
Host
Hamster
Clonality
Monoclonal
Conjugate
This CTLA4 antibody is conjugated to Biotin
Application
Intracellular Flow Cytometry (ICFC)
Purification
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
CD152, also known as CTLA-4 or Ly-56, is a 33 kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.