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FLT4 antibody

FLT4 Reactivity: Mouse FACS Host: Rat Monoclonal AFL4 unconjugated
Catalog No. ABIN2665457
  • Target See all FLT4 Antibodies
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Reactivity
    • 81
    • 49
    • 16
    • 11
    Mouse
    Host
    • 72
    • 24
    • 8
    • 2
    Rat
    Clonality
    • 73
    • 33
    Monoclonal
    Conjugate
    • 56
    • 11
    • 7
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FLT4 antibody is un-conjugated
    Application
    • 57
    • 43
    • 37
    • 27
    • 14
    • 13
    • 13
    • 10
    • 8
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    AFL4
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product FLT4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Alternative Name
    VEGFR-3 (FLT4 Products)
    Synonyms
    FLT41 antibody, LMPH1A antibody, PCL antibody, VEGFR3 antibody, AI323512 antibody, Chy antibody, Flt-4 antibody, VEGFR-3 antibody, Vegfr3 antibody, cb1059 antibody, fms related tyrosine kinase 4 antibody, FMS-like tyrosine kinase 4 antibody, fms-related tyrosine kinase 4 antibody, FLT4 antibody, Flt4 antibody, flt4 antibody
    Background
    VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis.
    Pathways
    RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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