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CD80 antibody

CD80 Reactivity: Human FACS Host: Mouse Monoclonal L307-4 unconjugated
Catalog No. ABIN2689406
  • Target See all CD80 Antibodies
    CD80
    Reactivity
    • 131
    • 94
    • 43
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 87
    • 63
    • 21
    • 16
    • 7
    • 1
    • 1
    Mouse
    Clonality
    • 116
    • 77
    • 2
    Monoclonal
    Conjugate
    • 82
    • 16
    • 15
    • 14
    • 11
    • 6
    • 3
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD80 antibody is un-conjugated
    Application
    • 113
    • 91
    • 67
    • 31
    • 29
    • 19
    • 14
    • 13
    • 13
    • 12
    • 11
    • 10
    • 9
    • 4
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    • 1
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    Flow Cytometry (FACS)
    Brand
    BD Pharmingen™
    Characteristics
    Reacts with B7/BB1, a 60 kDa transmembrane glycoprotein which was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens. CD80, a member of the Ig supergene family, is expressed on activated B cells, macrophages, and dendritic cells. It is the ligand for two molecules expressed on T cells, CD28 and CD152 (CTLA-4). CD80 is also expressed on activated CD4+ and CD8+ T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway. The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production. Profile of human CD80 expressed on Raji cell line analyzed by flow cytometry

    BD Pharmingen™ Purified Mouse Anti-Human CD80 - Purified - Clone L307.4 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Clone
    L307-4
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD80 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Azuma, Yssel, Phillips, Spits, Lanier: "Functional expression of B7/BB1 on activated T lymphocytes." in: The Journal of experimental medicine, Vol. 177, Issue 3, pp. 845-50, (1993) (PubMed).

    Schwartz: "Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy." in: Cell, Vol. 71, Issue 7, pp. 1065-8, (1993) (PubMed).

    Koulova, Clark, Shu, Dupont: "The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells." in: The Journal of experimental medicine, Vol. 173, Issue 3, pp. 759-62, (1991) (PubMed).

  • Target
    CD80
    Alternative Name
    CD80 (CD80 Products)
    Synonyms
    B7 antibody, B7-1 antibody, B7.1 antibody, BB1 antibody, CD28LG antibody, CD28LG1 antibody, LAB7 antibody, B71 antibody, Cd28l antibody, Ly-53 antibody, Ly53 antibody, MIC17 antibody, TSA1 antibody, CD80 molecule antibody, Cd80 molecule antibody, CD80 antigen antibody, CD80 antibody, Cd80 antibody
    Background
    Synonyms: B7-1
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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