SMAD4
Reactivity: Human
ELISA, IHC, IF, DB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
DO NOT FREEZE!
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C.
Nagappan, Park, Park, Kim, Hong, Kang, Zhang, Kim, Lee, Won, Kim: "Proteomic analysis of differentially expressed proteins in vitamin C-treated AGS cells." in: BMC biochemistry, Vol. 14, pp. 24, (2014) (PubMed).
Yang, Zhao, Rasul, Qin, Li, Li: "PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis." in: Cell death & disease, Vol. 4, pp. e811, (2013) (PubMed).
Yang, Li, Wang, Wang, Li, Yang, Peng: "Smad4 disruption accelerates keratinocyte reepithelialization in murine cutaneous wound repair." in: Histochemistry and cell biology, Vol. 138, Issue 4, pp. 573-82, (2012) (PubMed).
Izumi, Nakamura, Tokumo, Mano: "A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas." in: JOP : Journal of the pancreas, Vol. 12, Issue 5, pp. 464-8, (2011) (PubMed).
Yuan, Wang, Hu, Li, Jing: "Transforming growth factor-?/Smad signaling function in the aortopathies." in: Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular, Vol. 26, Issue 3, pp. 393-403, (2011) (PubMed).
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Background
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.Synonyms: DPC4, Deletion target in pancreatic carcinoma 4, MAD homolog 4, MADH4, Mothers against DPP homolog 4, Mothers against decapentaplegic homolog 4, SMAD 4, SMAD family member 4, SMAD-4