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TRAIL antibody (AA 95-281)
TNFSF10
Reactivity: Human
FACS
Host: Mouse
Monoclonal
2E5
unconjugated
Product Details anti-TRAIL Antibody
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Target
See all TRAIL (TNFSF10) Antibodies
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Binding Specificity
All epitopes for TRAIL antibodies
AA 95-281
Reactivity
All reactivities for TRAIL antibodies
Human
Host
All hosts for TRAIL antibodies
Mouse
Clonality
All clonalities for TRAIL antibodies
Monoclonal
Conjugate
All conjugates for TRAIL antibodies
This TRAIL antibody is un-conjugated
Application
All applications for TRAIL antibodies
Flow Cytometry (FACS)
Specificity
The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
No Cross-Reactivity
Mouse
Cross-Reactivity (Details)
Human
Purification
Purified by protein-A affinity chromatography.
Purity
> 95 % (by SDS-PAGE)
Immunogen
Recombinant soluble fragment (aa 95-281) of human TRAIL.
Clone
2E5
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Flow cytometry: Recommended dilution: 1-5 μg/mL.
Restrictions
For Research Use only
Handling
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Concentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store at 2-8°C. Do not freeze.
References for anti-TRAIL antibody (ABIN2751999)
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Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed : "Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. " in: Cancer research , Vol. 65 , Issue 11 , pp. 4799-808 , (2005 ) (PubMed ).
Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka : "TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. " in: Leukemia , Vol. 16 , Issue 1 , pp. 67-73 , (2002 ) (PubMed ).
Target Details for TRAIL
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Target
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Alternative Name
CD253 / TRAIL (TNFSF10 Products )
Synonyms
APO2L antibody, Apo-2L antibody, CD253 antibody, TL2 antibody, TRAIL antibody, A330042I21Rik antibody, AI448571 antibody, APO-2L antibody, Ly81 antibody, Trail antibody, tl2 antibody, apo2l antibody, cd253 antibody, trail antibody, apo-2l antibody, trail1 antibody, xtrail1 antibody, tnfsf10l2 antibody, zgc:92320 antibody, TNLG6A antibody, TNF superfamily member 10 antibody, tumor necrosis factor (ligand) superfamily, member 10 antibody, tumor necrosis factor superfamily member 10 antibody, TNF superfamily member 10 S homeolog antibody, TNFSF10 antibody, Tnfsf10 antibody, tnfsf10.S antibody, tnfsf10 antibody
Background
TNF superfamily member 10,Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).,TRAIL, Apo-2 ligand, Apo-2L, TNFSF10, APO2L, TNLG6A
Gene ID
8743
UniProt
P50591
Pathways
Apoptosis , Positive Regulation of Endopeptidase Activity
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