FZD4 antibody (Frizzled Family Receptor 4) (Middle Region)

Details for Product anti-FZD4 Antibody No. ABIN2776715, Supplier: Log in to see
Antigen
  • CG4626
  • DFz4
  • Dfz4
  • Dm Fz4
  • Dmel\\CG4626
  • Fz4
  • anon-WO0170980.10
  • anon-WO0170980.11
  • fz1
  • zg01
  • CD344
  • EVR1
  • FEVR
  • FZD4S
  • Fz-4
  • FzE4
  • GPCR
  • hFz4
  • frizzled4
  • fz4
  • FZ-4
  • frizzled 4
  • frizzled homolog 4
  • frizzled-4
  • frizzled family receptor 4
  • frizzled homolog 4 (Drosophila)
  • fz4
  • fzd4
  • Tsp_10376
  • FZD4
  • Fzd4
Alternatives
anti-Human FZD4 antibody for Immunofluorescence (fixed cells)
Epitope
Middle Region
27
15
13
11
10
9
8
4
4
3
3
2
2
2
1
1
1
1
Reactivity
Cow (Bovine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus)
127
76
52
7
7
7
7
5
5
5
5
4
2
2
2
1
Host
Rabbit
80
25
22
8
Clonality
Polyclonal
Conjugate
This FZD4 antibody is un-conjugated
8
6
4
4
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
73
52
25
15
13
11
11
6
2
1
1
1
Options
Supplier
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human FZD4
Blocking Peptide Blocking peptide for this product available: ABIN977169
Sequence GITSGMWIWS AKTLHTWQKC SNRLVNSGKV KREKRGNGWV KPGKGSETVV
Predicted Reactivity Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against FZD4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name FZD4 (FZD4 Antibody Abstract)
Background FZD4 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EVR1, FEVR, FZD4S, Fz-4, FzE4, GPCR, MGC34390, CD344
Protein Interaction Partner: UBC, NDP, ZNRF3, BAG6, MAGI3, DLG2, DLG4, DVL2, DLG1, ARRB2,
Protein Size: 537
Molecular Weight 60 kDa
Gene ID 8322
NCBI Accession NM_012193, NP_036325
UniProt Q9ULV1
Pathways WNT Signaling, Hormone Transport, Sensory Perception of Sound
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 537 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-FZD4 antibody (Frizzled Family Receptor 4) (Middle Region) (ABIN2776715) anti-Frizzled Family Receptor 4 (FZD4) (Middle Region) antibody
Product cited in: Wang, Pawlak, Johnson, Belknap, Eades, Stack, Cousin, Black: "Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae." in: PLoS ONE, Vol. 8, Issue 2, pp. e56025, 2013 (PubMed).

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35553, 2012 (PubMed).

Gonzalez, Fernandez-Martos, Gonzalez-Fernandez, Arenas, Rodriguez: "Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats." in: PLoS ONE, Vol. 7, Issue 12, pp. e50793, 2012 (PubMed).

Background publications Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: "Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation." in: The American journal of pathology, Vol. 172, Issue 1, pp. 37-49, 2008 (PubMed).