Aprataxin antibody (Middle Region)
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- Target See all Aprataxin (APTX) Antibodies
- Aprataxin (APTX)
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Binding Specificity
- Middle Region
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Reactivity
- Human, Guinea Pig, Dog, Rabbit, Horse, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Aprataxin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- YPYIVEFEEE AKNPGLETHR KRKRSGNSDS IERDAAQEAE AGTGLEPGSN
- Predicted Reactivity
- Cow: 77%, Dog: 86%, Guinea Pig: 79%, Horse: 92%, Human: 100%, Rabbit: 86%
- Characteristics
- This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human APTX
- Top Product
- Discover our top product APTX Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 306 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Aprataxin (APTX)
- Alternative Name
- APTX (APTX Products)
- Synonyms
- aptx antibody, APTX antibody, LOC100284636 antibody, APRATAXIN-like antibody, T10O8.20 antibody, T10O8_20 antibody, AOA antibody, AOA1 antibody, AXA1 antibody, EAOH antibody, EOAHA antibody, FHA-HIT antibody, 2410016G21Rik antibody, AA388047 antibody, aprataxin antibody, FHA-HIT antibody, APRATAXIN-like protein antibody, aprataxin L homeolog antibody, aptx antibody, APTX antibody, CpipJ_CPIJ001673 antibody, LOC100284636 antibody, aptx.L antibody, Aptx antibody
- Background
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APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined. This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT, FLJ20157, MGC1072
Protein Interaction Partner: PNMA1, UBC, SUMO1, NEDD8, LIG3, HSPA4, XRCC1, DDX21, CNTROB, TSPYL2, CALCOCO1, SYT17, ZNF639, MAPKBP1, CEP350, PICK1, XRCC4, TRIM37, MBP, HIVEP1, BANF1, PARP1, TP53,
Protein Size: 306 - Molecular Weight
- 35 kDa
- Gene ID
- 54840
- NCBI Accession
- NM_175069, NP_778239
- UniProt
- Q5T782
- Pathways
- DNA Damage Repair, Chromatin Binding
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