PML antibody (Middle Region)
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- Target See all PML Antibodies
- PML (Promyelocytic Leukemia (PML))
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Binding Specificity
- Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PML antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- TTLPPAQPAF NLQALGTYFE GLLEGPALAR AEGVSTPLAG RGLAERASQQ
- Specificity
- Isoform 1, 9, 10 and 11 specific
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PML. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PML
- Top Product
- Discover our top product PML Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 882 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PML (Promyelocytic Leukemia (PML))
- Alternative Name
- PML (PML Products)
- Synonyms
- MYL antibody, PP8675 antibody, RNF71 antibody, TRIM19 antibody, 1200009E24Rik antibody, AI661194 antibody, Trim19 antibody, RGD1562602 antibody, PML antibody, promyelocytic leukemia antibody, PML antibody, Pml antibody
- Background
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PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor an
Alias Symbols: MYL, PP8675, RNF71, TRIM19
Protein Interaction Partner: RPL11, RPL5, SUMO1, UBC, TP53, SUMO2, SUMO3, MDM2, RNF4, EGFR, NCOA2, SP100, DAXX, MAPK7, HDAC1, ATXN1, ATRX, ASF1A, EHMT2, HIRA, HTT, H3F3A, ATF7IP, PML, JAK1, EIF4E, GLIS2, UBE2I, smt3, HDAC11, HDAC6, LMNA, RNF111, CDK6, CDK2, CDK1, CASP8AP2, RBX1, SH3G
Protein Size: 882 - Molecular Weight
- 97 kDa
- Gene ID
- 5371
- NCBI Accession
- NM_033238, NP_150241
- UniProt
- P29590
- Pathways
- p53 Signaling, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
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