HNF1B antibody (N-Term)
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- Target See all HNF1B Antibodies
- HNF1B (HNF1 Homeobox B (HNF1B))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Cow, Horse, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HNF1B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LETLPLSPGS GAEPDTKPVF HTLTNGHAKG RLSGDEGSED GDDYDTPPIL
- Specificity
- 100 % specific to all three isoforms of HNF1B (61, 58, 45kD).
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against HNF1B. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human HNF1B
- Top Product
- Discover our top product HNF1B Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 399 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- HNF1B (HNF1 Homeobox B (HNF1B))
- Alternative Name
- HNF1B (HNF1B Products)
- Synonyms
- FJHN antibody, HNF-1B antibody, HNF1beta antibody, HNF2 antibody, HPC11 antibody, LF-B3 antibody, LFB3 antibody, MODY5 antibody, TCF-2 antibody, TCF2 antibody, VHNF1 antibody, HNF-1b antibody, HNF1B antibody, AI385728 antibody, AI987804 antibody, HNF-1Beta antibody, Hnf1beta antibody, Tcf-2 antibody, Tcf2 antibody, vHNF1 antibody, vHNF-1 antibody, chunp6877 antibody, hnf1b antibody, mst antibody, tcf2 antibody, vhnf1 antibody, lfb3 antibody, hnf-1beta antibody, hnf1-beta antibody, hnf1beta antibody, HNF1g antibody, wu:fc23f06 antibody, HNF1 homeobox B antibody, HNF1 homeobox Ba antibody, HNF1 homeobox B S homeolog antibody, HNF1 homeobox B L homeolog antibody, HNF1 homeobox Bb antibody, HNF1B antibody, Hnf1b antibody, hnf1ba antibody, hnf1b.S antibody, hnf1b.L antibody, hnf1bb antibody
- Background
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Hepatocyte Nuclear Factor 1-. (HNF-1., Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor ) is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The TCF2 protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1, depending on the TCF2 isoform, the result may be to activate or inhibit transcription of target genes. Mutation of TCF2 that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5). A third human transcript variant is believed to exist based on such a variant in the rat: however, to date such an mRNA species has not been isolated.
Alias Symbols: FJHN, HNF1beta, HNF2, LFB3, MODY5, TCF2, VHNF1, HPC11, LF-B3
Protein Interaction Partner: HIST1H3A, PCBD1, CREBBP, HNF1A, ATF1, CREB1,
Protein Size: 399 - Molecular Weight
- 45 kDa
- Gene ID
- 6928
- NCBI Accession
- NM_006481, NP_006472
- UniProt
- P35680
- Pathways
- Hormone Transport, Stem Cell Maintenance, Tube Formation
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