MDH2 antibody (Malate Dehydrogenase 2, NAD (Mitochondrial)) (C-Term)

Details for Product anti-MDH2 Antibody No. ABIN2783318, Supplier: Log in to see
Antigen
  • Mdh2b
  • m-mdh
  • mdh2
  • mor1
  • MDH-2
  • Mdh
  • wu:fj48c08
  • wu:fj55d06
  • zgc:64133
  • M-MDH
  • MDH
  • MGC:3559
  • MOR1
  • MMDH
  • Mdh-2
  • Mor-1
  • Mor1
  • malate dehydrogenase 2, NAD (mitochondrial)
  • Malate dehydrogenase 2
  • malate dehydrogenase
  • mdh2-b
  • MDH2
  • Mdh2
  • MDH4
  • mdh2
Epitope
C-Term
13
10
8
6
5
4
4
3
3
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
62
22
13
2
1
1
1
1
1
Host
Rabbit
47
14
2
Clonality
Polyclonal
Conjugate
This MDH2 antibody is un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
53
33
17
15
6
6
3
3
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human MDH2
Sequence TYFSTPLLLG KKGIEKNLGI GKVSSFEEKM ISDAIPELKA SIKKGEDFVK
Predicted Reactivity Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
Characteristics This is a rabbit polyclonal antibody against MDH2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name MDH2 (MDH2 Antibody Abstract)
Background Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: M-MDH, MDH, MGC:3559, MOR1
Protein Interaction Partner: FUS, HUWE1, GRSF1, UBC, MDM2, PARK2, UBD, METTL21B, VCAM1, ITGA4, FN1, ATF2, LDHAL6A, MRPS28, IDH1, CLNS1A, SERPINH1, ATP5B, ATP5A1, CRYAB, COPS5, CDK2, PSMA3, PCNA, HDAC5, Mapk13, PSMD4, PC, WARS, NDUFS1, MDH2, GOT2, FH, CS,
Protein Size: 338
Molecular Weight 33 kDa
Gene ID 4191
NCBI Accession NM_005918, NP_005909
UniProt P40926
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 338 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Malate Dehydrogenase 2, NAD (Mitochondrial) (MDH2) (C-Term) antibody (ABIN2783318) WB Suggested Anti-MDH2 Antibody Titration: 2.5ug/ml
Positive Control:
Western Blotting (WB) image for anti-Malate Dehydrogenase 2, NAD (Mitochondrial) (MDH2) (C-Term) antibody (ABIN2783318) anti-Malate Dehydrogenase 2, NAD (Mitochondrial) (MDH2) (C-Term) antibody (Image 2)
Product cited in: Freund, Prenni, Curthoys: "Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis." in: American journal of physiology. Renal physiology, Vol. 304, Issue 2, pp. F145-55, 2013 (PubMed).

Povlsen, Løfgren, Dalgas, Birkler, Johannsen, Støttrup, Bøtker: "Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation." in: PLoS ONE, Vol. 8, Issue 5, pp. e64093, 2013 (PubMed).

Background publications Rzem, Vincent, Van Schaftingen, Veiga-da-Cunha: "L-2-hydroxyglutaric aciduria, a defect of metabolite repair." in: Journal of inherited metabolic disease, Vol. 30, Issue 5, pp. 681-9, 2007 (PubMed).

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