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FGFR1 antibody (N-Term)
FGFR1
Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FGFR1 Antibody
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Target
See all FGFR1 Antibodies
FGFR1
(Fibroblast Growth Factor Receptor 1 (FGFR1))
Binding Specificity
All epitopes for FGFR1 antibodies
N-Term
Reactivity
All reactivities for FGFR1 antibodies
Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse
Host
All hosts for FGFR1 antibodies
Rabbit
Clonality
All clonalities for FGFR1 antibodies
Polyclonal
Conjugate
All conjugates for FGFR1 antibodies
This FGFR1 antibody is un-conjugated
Application
All applications for FGFR1 antibodies
Western Blotting (WB)
Sequence
TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNRRPV APYWTSPEKM
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Characteristics
This is a rabbit polyclonal antibody against Fgfr1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Fgfr1
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Discover our top product FGFR1 Primary Antibody
Alternatives
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Application Details
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Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for FGFR1
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Target
FGFR1
(Fibroblast Growth Factor Receptor 1 (FGFR1))
Alternative Name
Fgfr1 (FGFR1 Products )
Synonyms
FGFR antibody, fgfr antibody, X1FGFR antibody, XFGFR-1 antibody, XFGFRA2 antibody, bfgfr antibody, cek antibody, fgfr1 antibody, flg antibody, flt-2 antibody, flt2 antibody, kal2 antibody, ogd antibody, xfgfr1 antibody, CG7223 antibody, CT22273 antibody, CT39172 antibody, DFGF-R1 antibody, DFGF-R2 antibody, DFR-1 antibody, DFR1 antibody, DFR1/DFGF-R2 antibody, DPR3 antibody, DTRK(FR1) antibody, Dfr-1 antibody, Dfr1 antibody, DmHD-38 antibody, Dmel\\CG7223 antibody, Dtk1 antibody, EMS2 antibody, FGF-R2 antibody, FGFR2 antibody, FR1 antibody, Fr1 antibody, HD-38 antibody, HTL/FGFR1 antibody, Htl antibody, Tk1 antibody, dtk1 antibody, i100 antibody, i150 antibody, i79 antibody, j372 antibody, cd331 antibody, fgfbr antibody, fgfr-1 antibody, hbgfr antibody, n-sam antibody, ach antibody, cd333 antibody, cek2 antibody, fgfr-3 antibody, hsfgfr3ex antibody, jtk4 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR-1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, HBGFR antibody, HH2 antibody, KAL2 antibody, N-SAM antibody, OGD antibody, bFGF-R-1 antibody, AW208770 antibody, Eask antibody, Fgfr-1 antibody, Flt-2 antibody, Hspy antibody, FLG-1 antibody, FGFRI antibody, x1fgfr antibody, cb231 antibody, sb:cb231 antibody, fibroblast growth factor receptor antibody, fibroblast growth factor receptor 1 S homeolog antibody, basic fibroblast growth factor receptor 1 antibody, heartless antibody, fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog antibody, Fibroblast growth factor receptor 1 antibody, fibroblast growth factor receptor 1 L homeolog antibody, fibroblast growth factor receptor 1a antibody, FGFR antibody, fgfr antibody, fgfr1.S antibody, CpipJ_CPIJ005849 antibody, htl antibody, fgfr1 antibody, fgfr3.L antibody, FGFR1 antibody, Fgfr1 antibody, fgfr1.L antibody, fgfr1a antibody
Background
Fgfr1 is a Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Fgfr1 phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. It promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, Fgfr1 enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation Alias Symbols: AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy Protein Interaction Partner: GZMB, Fgf23, Kl, Frs2, Protein Size: 822
Molecular Weight
92 kDa
Gene ID
14182
NCBI Accession
NM_010206 , NP_034336
UniProt
P16092
Pathways
RTK Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Sensory Perception of Sound , Stem Cell Maintenance , S100 Proteins
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