Macrophage Scavenger Receptor 1 antibody (N-Term)
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- Target See all Macrophage Scavenger Receptor 1 (MSR1) Antibodies
- Macrophage Scavenger Receptor 1 (MSR1)
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Binding Specificity
- N-Term
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Reactivity
- Human, Pig, Dog, Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Macrophage Scavenger Receptor 1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN
- Predicted Reactivity
- Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%
- Characteristics
- This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product MSR1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 451 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Macrophage Scavenger Receptor 1 (MSR1)
- Alternative Name
- MSR1 (MSR1 Products)
- Synonyms
- CD204 antibody, SCARA1 antibody, SR-A antibody, SRA antibody, phSR1 antibody, phSR2 antibody, MRS-A antibody, MSR antibody, MSR-A antibody, SR-AI antibody, SR-AII antibody, Scara1 antibody, Scvr antibody, MSR1 antibody, RGD1564316 antibody, macrophage scavenger receptor 1 antibody, scavenger receptor class A member 5 antibody, MSR1 antibody, Msr1 antibody, SCARA5 antibody
- Background
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This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Alias Symbols: CD204, SCARA1, SR-A, phSR1, phSR2, SRA
Protein Interaction Partner: SEC22A, LEPROTL1, MALL, NKG7, ATP6V0C, IQCB1, TRAF6, HSPA1A,
Protein Size: 451 - Molecular Weight
- 50 kDa
- Gene ID
- 4481
- NCBI Accession
- NM_138715, NP_619729
- UniProt
- P21757
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