EPC-1 antibody, OI12 antibody, OI6 antibody, PEDF antibody, MGC82984 antibody, SERPINF1 antibody, AI195227 antibody, Pedf antibody, Pedfl antibody, Sdf3 antibody, Dmrs91 antibody, zgc:92072 antibody, serpin family F member 1 antibody, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 antibody, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog antibody, serine (or cysteine) peptidase inhibitor, clade F, member 1 antibody, SERPINF1 antibody, serpinf1 antibody, serpinf1.L antibody, Serpinf1 antibody
Background
Pigment Epithelium-Derived Factor ( PEDF ), a protein previously shown to have neurotrophic activity,is indispensable for neuronal development, differentiation and existence adjacent to retina.The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygenconcentrations,suggesting that its loss play a permissive role in ischemia-driven retinal neovascularization.So that, PEDF is likely to contribute to regulate of blood vessels growth in eye by creating a permissiveenvironment for angiogenesis when oxygen is limiting and an inhibitory environment oxygenconcentrations are normal or high ( Science Vol 285: 245-248,1999).PEDF may be a therapeutic target pathologic ocular neovascularization as well as for retinoblastomas.This antibody could detect PEDF with western-blotting method in medium of retinal pigment epitheliumcell. This antibody is useful in research for angionenesis and neuronal system.