Advanced Glycosylation End Product-Specific Receptor (AGER) antibody

Antigen: Advanced Glycosylation End Product-Specific Receptor (AGER)

Synonyms: RAGE, MGC22357, AGER, MGC140817

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN289974

Additional Information

Alternative name: RAGE

Immunogen: Partial peptide of Human RAGE

Format: Affinity-purified

Description: RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecularweight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been foundin several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand ofRAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE,N-carboxymethyllysine(CML),beta-amyloid and so on. The accumulation of AGEs-proteins invivo has been demonstrated in several disease, it is not clear whether AGEs-proteinsaccumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE isinvolved in pathophysiological function of diabetes and Alzheimer

Application Details

Concentration: 0.25 mg/ml

Purification: This antibody was purified from rabbit serum by Protein G affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Storage: Store below -20

Restrictions: For Research Use only

Images

Western blotting Sample: Cell lysates ofCHO-RAGE or A549 cells (5ug/lane). Preparation of antibodies and instruction: Prof. S Horiuch., Department of Biochemistry KumamotoUniversity School of Medicine