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ICAM-1 antibody (Intercellular Adhesion Molecule 1) (APC)

Details for Product anti-ICAM1 Antibody No. ABIN302239, Supplier: Log in to see
Antigen
  • BB2
  • CD54
  • ICAM
  • ICAM-1
  • Icam-1
  • ICAM1
  • Ly-47
  • MALA-2
  • P3.58
Reactivity
Human
740
178
150
26
8
7
1
1
1
Host
Mouse
586
253
95
10
9
5
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This ICAM-1 antibody is conjugated to APC
87
83
83
20
19
19
13
11
9
9
9
8
8
8
8
8
6
5
5
5
5
4
4
4
4
4
4
3
3
2
1
1
1
1
Application
Flow Cytometry (FACS)
562
376
235
209
197
155
148
67
50
45
42
29
20
12
12
10
9
8
6
6
6
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Supplier
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Immunogen Raji cells and spleen cells fused with NS1 cells
Clone 1H4
Isotype IgG2b
Characteristics Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
Purification Size-exclusion chromatography
Alternative Name CD54 / ICAM1 (ICAM1 Antibody Abstract)
Background CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
UniProt P05362
Application Notes Flow Cytometry analysis of human blood cells using 10 l reagent / 100 l of whole bloodor 10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Ockenhouse, Betageri, Springer, Staunton: "Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus." in: Cell, Vol. 68, Issue 1, pp. 63-9, 1992 (PubMed).

Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Boyd, Dunn, Fecondo, Culvenor, Dührsen, Burns, Wawryk: "Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation." in: Blood, Vol. 73, Issue 7, pp. 1896-903, 1989 (PubMed).

Boyd, Wawryk, Burns, Fecondo: "Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 9, pp. 3095-9, 1988 (PubMed).