Retinoblastoma Protein (Rb) antibody

Catalog No. ABIN306636

The Mouse Monoclonal anti-Retinoblastoma Protein (Rb) antibody (Clone C36) (ABIN306636) specifically detects Retinoblastoma Protein (Rb) in IP. The antibody is reactive with Human, Mouse, Rat and Chicken samples.

Quick Overview for Retinoblastoma Protein (Rb) antibody (ABIN306636)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivity: Human, Mouse, Rat, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application: Immunoprecipitation (IP)

Clone: C36

Product Details anti-Retinoblastoma Protein (Rb) Antibody

Purpose: Mouse anti Human Rb (Retinoblastoma)

Characteristics: Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.

Purification: Protein A/G Chromatography

Isotype: IgG1

Application Details

Application Notes: Applications: Immunoprecipitation

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Alternative Name: Rb (Retinoblastoma)

Background: Retinoblastoma-associated protein, pRb, pp110, p105-Rb

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases