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Retinoblastoma Protein (Rb) antibody (pSer788)

Rb Protein Reactivity: Human DB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032467
$592.75
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  • Target See all Retinoblastoma Protein (Rb) (Rb Protein) Antibodies
    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
    Binding Specificity
    • 17
    • 15
    • 15
    • 15
    • 15
    • 11
    • 10
    • 9
    • 9
    • 8
    • 7
    • 7
    • 5
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    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer788
    Reactivity
    • 201
    • 79
    • 61
    • 8
    • 8
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 172
    • 30
    Rabbit
    Clonality
    • 170
    • 32
    Polyclonal
    Conjugate
    • 96
    • 19
    • 11
    • 10
    • 10
    • 10
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    This Retinoblastoma Protein (Rb) antibody is un-conjugated
    Application
    • 111
    • 109
    • 101
    • 38
    • 32
    • 22
    • 19
    • 15
    • 3
    • 1
    Dot Blot (DB), Immunohistochemistry (IHC), ELISA
    Purification
    Antigen affinity purified
    Immunogen
    This phospho-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS788 of human Rb.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the phospho-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the phospho-Rb antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
    Alternative Name
    Retinoblastoma / Rb (Rb Protein Products)
    Background
    RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
    UniProt
    P06400
    Pathways
    Mitotic G1-G1/S Phases
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