CYP1A2 antibody

Catalog No. ABIN307111

Product Details anti-CYP1A2 Antibody

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP1A2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Characteristics: CYPIA2, P450-P3, P(3)450, P450 4,P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. Several P450 enzymes have been classified by sequence similarities as members of the CYP1A and CYP2A subfamilies. NADPH cytochrome 450 reductase is a microsomal enzyme responsible for the transfer of electrons from NADPH to cytochrome P450 enzymes during the P450 catalytic cycle. NADPH cytochrome P450 reductase is localized to the endoplasmic reticulum where it is also able to transfer electrons to heme oxygenase and cytochrome 5. NADPH cytochrome P450 reductase is structurally related to two separate flavoprotein families, ferredoxin nucleotide reductase (FNR) and flavodoxin. Electron transfer of NADPH cytochrome P450 reductase requires the binding of two flavin cofactors, FAD and FMN, to the FNR and flavodoxin domains, respectively.

Purification: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with rat cytochrome p450 proteins and mouse myeloma Ag8563 cells.

Clone: 3B8C1

Isotype: IgG1

Application Details

Application Notes: Antibody can be used for Western blotting (1-2 μg/mL) and immunohistochemistry (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for CYP1A2

Target: CYP1A2 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 (CYP1A2))

Alternative Name: Cytochrome P450 1A2 (CYP1A2 Products)

Synonyms: CP12 antibody, P3-450 antibody, P450(PA) antibody, CYP1A2 antibody, CYPIA2 antibody, P450-PM4 antibody, Cyp1a1 antibody, P450-3 antibody, CYPD45 antibody, P-450d antibody, RATCYPD45 antibody, CYP1A5 antibody, CP450 antibody, CYP-IA2 antibody, cytochrome P450 family 1 subfamily A member 2 antibody, cytochrome P450 1A2 antibody, cytochrome P450 LM4 antibody, cytochrome P450, family 1, subfamily A, polypeptide 2 antibody, cytochrome P450, family 1, subfamily a, polypeptide 2 antibody, cytochrome P450 1A2-like antibody, CYP1A2 antibody, LOC100328937 antibody, Cyp1a2 antibody, VDBG_06455 antibody, LOC101825565 antibody, LOC102130662 antibody

UniProt: P05177