Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) (N-Term) antibody

Details for Product No. ABIN310067
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Antigen
Synonyms 2810431B21Rik, 6720478K01Rik, Fars1, COXPD14, FARS1, HSPC320, PheRS, dJ520B18.2
Epitope
N-Term
(4), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(16), (2), (2)
Host
Rabbit
(13), (3)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(16), (7), (5), (4), (2)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN310067
229.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human FARS2
Sequence VELLGKSYPQ DDHSNLTRKV LTRVGRNLHN QQHHPLWLIK ERVKEHFYKQ
Predicted Reactivity Rabbit : 100 %, Bovine : 90 %, Mouse : 90 %, Rat : 90 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against FARS2. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name FARS2
Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS2 is a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. FARS1 encodes a mitochondrially-located phenylalanine-tRNA synthetase (PheRS) which consists of a single polypeptide chain unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and the eukaryotic cytoplasm.
Molecular Weight 50 kDa
Gene ID 10667
NCBI Accession NP_006558, NM_006567
UniProt O95363
Research Area Chromatin and Nuclear Signaling, DNA/RNA, Metabolism, Amino Acids
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 451 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) (N-Term) antibody anti-Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) (N-Term) antibody
anti-Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) (N-Term) antibody (2) WB Suggested Anti-FARS2
Antibody Titration: 5.0 µg/mL ELISA Titer: 1:.2500
Positive Control: Transfected 293T
Background publications Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

General Zhang, Walker, Tamplin et al.: "Zfp206 regulates ES cell gene expression and differentiation." in: Nucleic acids research, Vol. 34, Issue 17, pp. 4780-90, 2006 (PubMed).

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