PLVAP antibody (Plasmalemma Vesicle Associated Protein) (Biotin)

Details for Product anti-PLVAP Antibody No. ABIN316983, Supplier: Log in to see
Antigen
  • MECA32
  • Pv1
  • FELS
  • PV-1
  • PV1
  • gp68
  • plasmalemma vesicle associated protein
  • plasmalemma vesicle associated protein-like
  • Plvap
  • PLVAP
  • LOC100343789
Reactivity
Mouse (Murine)
39
20
1
Host
Rat
30
20
9
Clonality (Clone)
Monoclonal ()
Conjugate
This PLVAP antibody is conjugated to Biotin
11
5
2
2
2
2
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
43
37
19
14
13
9
5
4
4
1
1
1
1
Options
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Clone MECA-32
Isotype IgG2a
Characteristics Synonyms: Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker,Endothelial cell surface marker, Endothelial Cell Antigen, Plasmalemma vesicle-associatedprotein, Fenestrated endothelial-linked structure protein
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Alternative Name PLVAP (PLVAP Antibody Abstract)
Background PLVAP is a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.Synonyms: Endothelial Cell Antigen, Endothelial cell marker, Endothelial cell surface marker, FELS, Fenestrated endothelial-linked structure protein, MECA-32 antigen, PV-1, PV1, Plasmalemma vesicle protein 1, Plasmalemma vesicle-associated protein
UniProt Q9BX97
Research Area Organelles
Application Notes Flow Cytometry. Immunohistochemistry on frozen sections: 1/10.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,1 mg/mL
Buffer Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3) and 1 % Bovine Serum Albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Hallmann, Mayer, Berg, Broermann, Butcher: "Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 202, Issue 4, pp. 325-32, 1995 (PubMed).